| Theme | Up‒to‒date of the Protection of Gastroenterological Cancers | |
|---|---|---|
| Title | Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma | |
| Publish Date | 2015/10 | |
| Author | Kazuhisa Kodama | Department of Internal Medicine and Gastroenterology, Tokyo Women's Medical University |
| Author | Makiko Taniai | Department of Internal Medicine and Gastroenterology, Tokyo Women's Medical University |
| Author | Etsuko Hashimoto | Department of Internal Medicine and Gastroenterology, Tokyo Women's Medical University |
| [ Summary ] | According to annual health checks, 9‒30 % of Japanese adults have nonalcoholic fatty liver disease (NAFLD) by ultrasonography, and the prevalence of nonalcoholic steatohepatitis (NASH) is estimated to be 3‒5 %. Among community‒diagnosed NAFLD patients, the incidence of overall mortality and liver‒related death is higher than the general population. The yearly cumulative incidence of hepatocellular carcinoma (HCC) in patients with cirrhotic NASH (NASH‒LC) is about 2 % and lower than cirrhosis resulting from hepatitis C (HCV‒LC). Older age, male gender, the complication of diabetes mellitus, advanced fibrosis, and oxidative stress are risk factors for HCC in NASH. It is important to consider the prognosis and potential for carcinogenesis of NAFLD/NASH when designing a treatment plan. | |