| Series | ||
|---|---|---|
| Title | A Case of Nonalcoholic Steatohepatitis after Pancreaticoduodenectomy | |
| Publish Date | 2014/07 | |
| Author | Yuji Kinoshita | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Akiyoshi Kinoshita | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Ken Tanaka | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Hiroshi Onoda | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Nami Imai | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Akira Iwaku | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Mutsumi Oishi | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Gou Kobayashi | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Hirohiko Kobayashi | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Nao Hushiya | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Syunichi Sakabe | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Hiroyuki Kijima | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Yoshinari Miyakawa | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Kazuhiko Koike | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Hirokazu Nishino | Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital |
| Author | Tomoyoshi Okamoto | Division of Hepato-Biliary-Pancreatic Surgery, The Jikei University Daisan Hospital |
| Author | Hisao Tajiri | Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine |
| [ Summary ] | A 63-year-old female underwent pancreaticoduodenectomy (PD) under a diagnosis of early duodenal cancer and intraductal papillary mucinous adenoma in February 2011. Postoperatively, she developed fatigue and her liver transaminase levels were elevated (AST/ALT : 750/800). She was admitted to another hospital for an examination in July 2011. However, the cause of the abnormalities remained unknown, and the liver dysfunction subsequently persisted for two years. She was referred to our hospital for a further investigation in February 2013 and admitted to our department in June 2013. A liver biopsy specimen revealed macrovesicular steatosis, ballooning degeneration of hepatocytes, lobular inflammation and perivenular fibrosis, consistent with a diagnosis of nonalcoholic steatohepatitis (NASH). Under a diagnosis of NASH after PD, the patient received pancreatic enzyme replacement therapy, and her liver transaminase levels subsequently decreased. Although NASH after PD is relatively rare, clinicians should be aware of the presentation of the disease | |