| Theme | Determination of Gastric Cancer Risk -- Current Conditions and Issues | |
|---|---|---|
| Title | Risk Assessment for Gastric Cancer in Relation to Clinical Epidemiology | |
| Publish Date | 2013/07 | |
| Author | Yoshiyuki Watanabe | Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science |
| Author | Shigeto Mizuno | Department of Medical Pharmaceutics, Kobe Pharmaceutical University |
| Author | Yasuko Matsukawa | Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science |
| Author | Hiroshi Hirohata | Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science |
| Author | Etsuko Ozaki | Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science |
| Author | Nagato Kuriyama | Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science |
| [ Summary ] | The use serological screening for gastric cancer is becoming more widely implemented in Japan. Techniques such as the 'ABC method' are used for determining serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels. However, positive results in terms of lowering mortality rates due to gastric cancer related causes have not been proven to be epidemiologically linked to the above method. Epidemiological studies have reported there is an increased risk of gastric cancer as levels of serologically determined atrophic gastritis rise. It is impossible to conduct randomized controlled trials on the 'ABC method' because screening for gastric cancer is more often accomplished with indirect X-ray examinations. Therefore, it is necessary to conduct trials concerning epidemiological evaluation of the 'ABC method' by conducting case-controlled studies or cohort studies in Japan. | |