| Theme | Complication of Inflammatory Bowel Disease | |
|---|---|---|
| Title | Intestinal Complications of Inflammatory Bowel Disease -- Pathology and Treatment of Stenosis and Fistula Associated with Crohnʼs Disease | |
| Publish Date | 2013/05 | |
| Author | Yuho Sato | Department of Gastroenterology, Fukuoka University Chikushi Hospital |
| Author | Fumihito Hirai | Department of Gastroenterology, Fukuoka University Chikushi Hospital |
| Author | Yutaka Yano | Department of Gastroenterology, Fukuoka University Chikushi Hospital |
| Author | Noritaka Takatsu | Department of Gastroenterology, Fukuoka University Chikushi Hospital |
| Author | Takahiro Beppu | Department of Gastroenterology, Fukuoka University Chikushi Hospital |
| Author | Toshiyuki Matsui | Department of Gastroenterology, Fukuoka University Chikushi Hospital |
| [ Summary ] | Intestinal complications such as stenosis and fistula often occur in Crohn's disease. The cumulative surgery rate for intestinal complications in Japan is 30 % at five years and 70 % at 10 years, with a repeat surgery rate of as high as approximately 50 % at 10 years. In cases of stenosis, endoscopic balloon dilation is effective to avoid frequent surgeries. However, it is necessary to preoperatively consider indications such as the degree of stenosis and the presence or absence of abscesses, fistulas, or curvature at the lesion site. When treating fistulas nutritional therapy and immunomodulatory agents may be effective for small internal fistulas, while biological agents may be effective for external fistulas. However, even small fistulas may be accompanied by abscess formation, and surgery is the standard treatment method. | |