| [ Summary ] |
Nonalcoholic fatty liver disease (NAFLD) is often present in patients with lifestyle related disease, such as hyperlipidemia, type 2 diabetes mellitus, hypertension, or metabolic syndrome. The aim of this retrospective cohort study was to assess the prevalence of and new developments in treating lifestyle related diseases. A total of 39,851 individuals (males 27,661, females 12,190) underwent the first round of multiphasic health screening examinations at the Toranomon Hospital. The prevalence of NAFLD was 20.8 % in males and 12.8 % in females. The prevalence of metabolic syndrome in patients with NAFLD was 32.4 % in males and 10.6 % in females. Development rate of type 2 diabetes mellitus in a group of 6,003 patients with NAFLD was 6.8 % in the 5th year and 17.7 % in the 10th year. The development rate for chronic kidney disease in a group of 5,561 patients with NAFLD was 3.1 % by the 5th year and 12.2 % by the 10th year. The 10 year cumulative development rate for coronary heart disease or cerebral stroke was 11.7 % out of 1,798 patients with NAFLD at the age of ≥ 60. Thus, our results show that physicians in charge of NAFLD patients should pay attention to the development and prevention of lifestyle related diseases. |