| Theme | NASH -- Pathogenesis and Treatment | |
|---|---|---|
| Title | Genome Wide Association Study on Pathogenesis of NASH | |
| Publish Date | 2013/04 | |
| Author | Takeshi Okanoue | Department of Gastroenterology & Hepatology, Saiseikai Suita Hospital |
| [ Summary ] | There is often an association between nonalcoholic steatohepatitis (NASH) and lifestyle related diseases such as diabetes mellitus, obesity, dyslipidemia and hypertension. However, the natural history of these conditions varies and the prognosis for NASH patients is complex. We performed a genome-wide association study (GWAS) recruiting 529 histologically diagnosed NAFLD patients and 932 individuals for the control group. A significant association was observed in the cluster of SNPs in PNPLA3s on chromosome 22q13 associated with rs738409. A subgroup analysis of NAFLD patients in contrast to the control group exhibited a significant association with rs738409 with type 4 NAFLD. The PNPLA3 gene is strongly associated with the progression of NASH in the Japanese population. | |