| Theme | Gastroenteropancreatic Neuroendocrine Tumors | |
|---|---|---|
| Title | Neuroendocrine Tumors in Colon and Rectum | |
| Publish Date | 2013/01 | |
| Author | Keiji Matsuda | The Department of Surgery, Teikyo University School of Medicine |
| Author | Tamuro Hayama | The Department of Surgery, Teikyo University School of Medicine |
| Author | Hideki Yamada | The Department of Surgery, Teikyo University School of Medicine |
| Author | Soichiro Ishihara | The Department of Surgery, Teikyo University School of Medicine |
| Author | Keijiro Nozawa | The Department of Surgery, Teikyo University School of Medicine |
| Author | Yojiro Hashiguchi | The Department of Surgery, Teikyo University School of Medicine |
| [ Summary ] | Neuroendocrine tumors in the colon and rectum are divided into two groups, carcinoid tumors and endocrine cell carcinomas (ECC). If the size of the carcinoid is 10 mm or under, endoscopic resection or local excision is appropriate. If it is from 11 to 20 mm and if located in the colon, RS or Ra, laparoscopicassisted surgery is appropriate. However, if it is located in the Rb or anal canal, the choice should be made carefully as to whether local resection or radical surgery to create a permanent colostomy should be performed. If the tumor is larger than 20 mm, or if it has invaded the muscularis propriae, radical surgery is required. For patients at increased risk of synchronous cancers, those with carcinoid tumors should undergo appropriate screening and surveillance. ECC displays highly proliferative activity and a high degree of metastases. The one-year survival rate for these cases is 10 to 15 %, which indicates very poor prognoses. Because surgical therapy has limited uses, effective chemotherapy regimens or radiotherapy are required. |
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