| Theme | Gastroenteropancreatic Neuroendocrine Tumors | |
|---|---|---|
| Title | Pancreatic and Gastrointestinal Neuroendocrine Tumors Associated with Multiple Endocrine Type 1 Neoplasias | |
| Publish Date | 2013/01 | |
| Author | Akihiro Sakurai | Department of Molecular Genetics, Shinshu University School of Medicine |
| [ Summary ] | Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominantly inherited neoplastic disorder which leads to development of various endocrine and non-endocrine tumors. Approximately 60 % of patients with MEN1 develop pancreatic NET (P-NET), while 10 % of all patients with PNET develop MEN1. Since P-NET accompanying MEN1 displays characteristic clinical features when compared to sporadic P-NET, those features help to provide a diagnosis of MEN1 early. Early diagnosis of MEN1 enables us to provide patients with appropriate management and makes it possible to provide presymptomatic diagnosis of MEN1 to relatives of patients. | |