| Theme | Diagnosis and Treatment of Lower Gastrointestinal Tract Submucosal Tumors | |
|---|---|---|
| Title | Diagnosis and Treatment of Colonic Granular Cell Tumors | |
| Publish Date | 2012/07 | |
| Author | Masao Hanafusa | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Hiroyasu Iishi | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Yoji Takeuchi | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Koji Higashino | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Noriya Uedo | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Ryu Ishihara | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| [ Summary ] | Colonic granular cell tumors (GCT) are a rare type of nonepithelial tumor which appear as submucosal tumors in the colon. These tumors are considered to be derived from Schwann cells. GCT is diagnosed with immunohistochemical methods similar to other nonepithelial tumors. They exhibit a positive reactions to S-100 protein staining. A differential diagnosis of colonic GCT or carcinoid tumors is impossible through endoscopic findings alone. Therefore, immunohistochemical examination of tissue specimens is necessary to produce a definitive diagnosis. In cases where GCT can not be employed to make a histological determination, diagnostic therapy, including endoscopic resection, may be implemented. However, in cases which have been diagnosed as being GCT, observation should be carried out to determine the presence of malignant colonic GCT conditions. |
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