| Theme | Non-B, Non-C Hepatocellular Carcinoma : The Latest Findings | |
|---|---|---|
| Title | The True State of Non-B Non-C Liver Cirrhosis in Japan | |
| Publish Date | 2012/05 | |
| Author | Tomoko Aoki | Department of Internal Medicine, Division of Hepatobiliary and Pancreatic Disease, Department of Ultrasound Center, Hyogo College of Medicine |
| Author | Hiroko Iijima | Department of Internal Medicine, Division of Hepatobiliary and Pancreatic Disease, Department of Ultrasound Center, Hyogo College of Medicine |
| Author | Shuhei Nishiguchi | Department of Internal Medicine, Division of Hepatobiliary and Pancreatic Disease, Hyogo College of Medicine |
| [ Summary ] | It was announced at the JDDW 2011 conference that the number of HBs Ag negative and HCV Ab negative liver cirrhosis (NBNC-LC) cases is gradually increasing. The rates of increase are as follows: 1998 21.8 %, 2008 24 % and 2011 26 %. In 2011, the frequency of alcohol related cases was 55.1 %, NASH related were 14.5 %, PBC related were 8 %, AIH were 6.8 %, fatty liver cases (based on steatohepatitis and alcohol consumption rates of 20-70 g/day) were 2.5 %, and the number of cases related to cryptogenic liver cirrhosis was 10.5 %. The frequency of alcohol related liver cirrhosis cases in 2011 was the same as in 2008. However, the frequency of NASH in 2011 was higher than in 2008 (14.5 % vs 8.7 %; P<0.001). Fatty liver cirrhosis has become a new criteria, which was developed at the JDDW2011 conference. It is characterized by complications due to diabetes mellitus, hyperlipemia, and hepatocellular carcinoma. It was determined that NBNC-HCCs cases were occasionally associated with occult HBV infections. We detected 9 HBV DNA related cases from serum and normal liver tissues of 32 NBNC-HCC patients by employing nested PCR. One involved integrated HBV DNA in the tumor tissue, as determined by Southern blot analysis. |
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