| Theme | Carcinogenesis Based on H. pylori-associated Gastritis -- Is Cancer Control Possible by the Eradication ? | |
|---|---|---|
| Title | Autofluorescence Imaging for Predicting Development of Metachronous Gastric Cancer after Helicobacter pylori Eradication | |
| Publish Date | 2012/03 | |
| Author | Noboru Hanaoka | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Noriya Uedo | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Yoji Takeuchi | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Koji Higashino | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Ryu Ishihara | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Hiroyasu Iishi | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| [ Summary ] | Although Helicobacter pylori eradication decreases the incidence of metachronous gastric cancer after endoscopic treatment for EGC, metachronous cancer may still develop after successful eradication, particularly in patients with severe corpus gastritis. We investigated whether the extent of atrophic fundic gastritis diagnosed by autofluorescence imaging (AFI) videoendoscopy is predictive of development of metachronous gastric cancer after H. pylori eradication in patients treated with ESD for EGC. Multivariate Coxʼs proportional hazard analysis revealed that opentype, atrophic fundic gastritis diagnosed by AFI was significantly (p＝0.018) associated with development of metachronous gastric cancer after adjustment for age, sex, histological intestinal metaplasia, serum pepsinogen levels, and H. pylori status (hazard ratio: 4.88, 95 % CI: 1.32-18.2). Metachronous EGC developed after successful H. pylori eradication. Extensive atrophic fundic gastritis diagnosed with AFI was a significant predictor. |
|