| Theme | Carcinogenesis Based on H. pylori-associated Gastritis -- Is Cancer Control Possible by the Eradication ? | |
|---|---|---|
| Title | Mucin Expression of Early Gastric Cancers Detected after Successful Eradication of Helicobacter pylori | |
| Publish Date | 2012/03 | |
| Author | Keiko Yamamoto | Department of Gastroenterology, Hokkaido University Graduate School of Medicine |
| [ Summary ] | A preventive effect of Helicobacter pylori eradication against the development of gastric cancer has recently been proven by the results of a randomized control trial and meta-analysis. However, gastric cancer is sometimes detected after successful eradication. There is a lack of studies concerning gastric cancer detected after H. pylori eradication. To clarify the characteristics of early gastric cancers detected after eradication, we analyzed the clinicopathological features of these cancers. Immunohistologically, 72.2 % of the lesions in the eradication group were complete gastric type or gastric predominant mixed type, whereas the proportion of gastric type and intestinal type in the control group were similar. The Ki-67 index was lower in the eradicated group. The clinicopathological characteristics of gastric cancers detected after H. pylori eradication were different from those of gastric cancers in patients with H. pylori infection. H. pylori eradication is thought to suppress intestinalization during the development of gastric cancer. |
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