| Theme | Carcinogenesis Based on H. pylori-associated Gastritis -- Is Cancer Control Possible by the Eradication ? | |
|---|---|---|
| Title | Clinicopathological Findings of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer with Confirmation of Negative Status for Current H. pylori Infection | |
| Publish Date | 2012/03 | |
| Author | Takeshi Nakajima | Endoscopy Division, National Cancer Center Hospital |
| Author | Shiko Kuribayashi | Endoscopy Division, National Cancer Center Hospital |
| Author | Ichiro Oda | Endoscopy Division, National Cancer Center Hospital |
| Author | Shigetaka Yoshinaga | Endoscopy Division, National Cancer Center Hospital |
| Author | Haruhisa Suzuki | Endoscopy Division, National Cancer Center Hospital |
| Author | Satoru Nonaka | Endoscopy Division, National Cancer Center Hospital |
| Author | Minori Matsumoto | Endoscopy Division, National Cancer Center Hospital |
| Author | Seiichiro Abe | Endoscopy Division, National Cancer Center Hospital |
| Author | Yutaka Saito | Endoscopy Division, National Cancer Center Hospital |
| [ Summary ] | Endoscopic submucosal dissection (ESD) for early gastric cancer has become widespread in Japan. Eradication therapy for Helicobacter pylori (H. pylori) has become a standard treatment after ESD. In this study, we analyzed metachronous gastric cancer (MGC) after ESD, as well as successful eradication therapy with confirmation of negative results for current H. pylori infection. Out of 553 follow up patients, 52 lesions were detected and determined to be positive for MGC in 41 patients. 47 lesions (92.2 %) were pathologically diagnosed as being the differentiated type of adenocarcinoma. On the other hand, 4 lesions (7.8 %) were diagnosed as being signet cell carcinoma. For further analysis, we must conduct long term follow up observations forpost ESD patients. | |