| Theme | Carcinogenesis Based on H. pylori-associated Gastritis -- Is Cancer Control Possible by the Eradication ? | |
|---|---|---|
| Title | Changes of Endoscopic and Histological Gastritis after Helicobacter pylori Eradication | |
| Publish Date | 2012/03 | |
| Author | Takashi Fujiwara | Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital |
| Author | Go Kuwata | Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital |
| Author | Sawako Kuruma | Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital |
| Author | Takeo Arakawa | Department of Endoscopy, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital |
| Author | Seishu Hayashi | Department of Hepatology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital |
| Author | Shinichiro Horiguchi | Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital |
| [ Summary ] | Helicobacter pylori infection causes chronic active gastritis by invading the gastric mucosa. Helicobacter pylori infection can be diagnosed through endoscopic findings such as diffuse redness, mucous adhesion, spotty redness, swelling, tortuosity of the gastric mucosa, and RAC. With endoscopic changes after eradication, diffuse redness, mucosal edema and spotty redness improve within three months. It takes a great deal of time to improve the condition of patients with enlarged fold gastritis or nodular gastritis. After eradication, new lesions may appear such as gastroduodenal erosions or red depressed areas caused by intestinal metaplasia. Xanthoma does not disappear after eradication. As H. pylori associated diseases, hyperplastic polyps and gastric MALT lymphoma disappear a comparatively high rate of complete remission is possible. Histlogical changes through eradication, neutrophilic infiltration of the gastric mucosa improve immediately, However, plasma cell and lymphocytic infiltration improve slowly. Histologic atrophy of the gastric mucosa also improve. |
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