| Theme | Current Therapy of IBD | |
|---|---|---|
| Title | Surgical Treatment for Ulcerative Colitis | |
| Publish Date | 2012/01 | |
| Author | Hiroki Ikeuchi | Inflammatory Bowel Disease Center / Department of Surgery, Hyogo College of Medicine |
| Author | Motoi Uchino | Inflammatory Bowel Disease Center / Department of Surgery, Hyogo College of Medicine |
| Author | Hiroki Matsuoka | Inflammatory Bowel Disease Center / Department of Surgery, Hyogo College of Medicine |
| Author | Toshihiro Bando | Inflammatory Bowel Disease Center / Department of Surgery, Hyogo College of Medicine |
| Author | Akihiro Hirata | Inflammatory Bowel Disease Center / Department of Surgery, Hyogo College of Medicine |
| Author | Naohiro Tomita | Department of Surgery, Hyogo College of Medicine |
| [ Summary ] | For patients with ulcerative colitis (UC) undergoing surgery, the median age at time of surgery was previously in the 20s, while recently it has shifted to the 30s. Moreover, the number of elderly patients over 60 years old has rapidly increased. Although options for medical treatment of UC are advancing, the prognosis after emergency surgery is extremely poor for elderly patients. Accordingly, it is a point of controversy as to whether they should be treated with the same therapy as younger patients. Pouchitis is the most frequent postoperative complication following surgery for UC, though the incidence in Japan is somewhat lower than that reported in Western countries. Nevertheless, the incidence of intractable pouchitis in daily clinical practice in Japan is rising and an important challenge for the immediate future is to establish effective therapies for intractable cases. However, even newly introduced treatments such as leukocyte removal therapy and anti-TNFα therapy have not provided fully satisfactory results. |
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