| Theme | Links Between Metabolic Syndrome and Colorectal Cancer |
|---|---|
| Title | Association of Obesitywith Colorectal Cancer Risk |
| Publish Date | 2011/02 |
| [ Summary ] | Recent evidence has indicated that obesity and related metabolic abnormalities increase the incidence of and mortality rates for various types of cancers. Known risk factors for colorectal cancers and adenomas include obesity, physical inactivity, visceral fat accumulation, hyperglycemia, and hyperinsulinemia. In contrast, body weight reduction is considerated to be a protective factor for colorectal cancers. Metabolic syndrome is characterized by a group of components associated with cardiovascular events. Recent epidemiological studies have suggested that in addition to the fact that metabolic syndrome is a cardiovascular risk factor, it can also be a risk factor for cancer, especially colorectal cancer. The factors associated with metabolic syndrome, including visceral fat accumulation, and hyperglycemia particularly increase the risk of colorectal cancer. One underlying biological mechanism may be insulin resistance and abnormal adipocytokines. Further studies are needed to elucidate the complete picture illustrating these underlying biological mechanisms, and to determine whether changes in life style and/or pharmacological treatments for metabolic abnormalities can protect patients from colorectal cancer. |