| Theme | Liver and Immunity | |
|---|---|---|
| Title | Hepatitis B and Innate Immunity | |
| Publish Date | 2011/10 | |
| Author | Tatsuo Kanda | Department of Gastroenterology, Chiba University Hospital |
| Author | Shuang Wu | Department of Gastroenterology, Chiba University Hospital |
| Author | Fumio Imazeki | Department of Gastroenterology, Chiba University Hospital |
| Author | Osamu Yokosuka | Department of Gastroenterology, Chiba University Hospital |
| [ Summary ] | Toll-like receptors (TLRs)-related signaling pathways are essential for the recognition of invading pathogens. These pathways contribute not only to innate but also adaptive immunity. We found that hepatitis B e antigen could directly suppress production of interferon and cytokines such as IL6 through inhibition of those pathways in human hepatocytes. Further studies to investigate these mechanisms are now going on. | |