| Theme | Current Status of Uprising Strategy for Esophageal Cancer Treatment | |
|---|---|---|
| Title | Predicting Effects of Chemoradiotherapy by Induction Chemotherapy Response Assessed by FDG-PET | |
| Publish Date | 2011/09 | |
| Author | Ryu Ishihara | Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Sachiko Yamamoto | Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Yoji Takeuchi | Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Koji Higashino | Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Noriya Uedo | Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Hiroyasu Iishi | Osaka Medical Center for Cancer and Cardiovascular Diseases |
| [ Summary ] | Background：We have developed a treatment protocol for esophageal cancer involving induction chemotherapy followed by chemoradiotherapy. This study aims to determine if it was possible to predict the effects of chemoradiotherapy on the basis of responses to induction chemotherapy, assessed by positron emission tomography (PET). Methods : Sixteen patients with Stage II-IV A esophageal cancer were treated using this protocol from April, 2007 to July, 2010. Chemotherapy involved a fluorouracil and platinum-based combination regimen. All patients received PET scans before, and 12-24 days after the beginning of induction chemotherapy. Associations between the response to induction chemotherapy assessed by PET and the effects of chemoradiotherapy were evaluated. Results：Using a cut-off value of 55 % for SUVmax reduction rate, most cancers with CR and without CR were correctly identified. Conclusions : Response to induction therapy assessed by PET was closely linked with the effects of chemoradiotherapy. |
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