| Theme | Autoimmune Pancreatitis | |
|---|---|---|
| Title | Extrapancreatic Lesions Associated with Autoimmune Pancreatitis | |
| Publish Date | 2010/08 | |
| Author | Terumi Kamisawa | Departments of Internal Medicine, Tokyo Metropolitan Komagome Hospital |
| Author | Kensuke Takuma | Departments of Internal Medicine, Tokyo Metropolitan Komagome Hospital |
| Author | Taku Tabata | Departments of Internal Medicine, Tokyo Metropolitan Komagome Hospital |
| Author | Naoto Egawa | Departments of Internal Medicine, Tokyo Metropolitan Komagome Hospital |
| Author | Koji Tsuruta | Department of Surgery, Tokyo Metropolitan Komagome Hospital |
| [ Summary ] | In patients with autoimmune pancreatitis (AIP), serum IgG4 concentrations are significantly elevated in spesific ways. Various extrapancreatic lesions such as sclerosing cholangitis, sclerosing sialadenitis, sclerosing dacryoadenitis, sclerosing cholangitis and retroperitoneal fibrosis are also frequently associated with this condition. The histological features of these extrapancreatic lesions are abundant infiltration of IgG4-positive plasma cells and T lymphocytes along with fibrosis and obliterative phlebitis, which are quite similar to those observed in the pancreas. Furthermore, it is apparent that abundant infiltration of IgG4-positive plasma cells is observed in various organs of AIP patients. AIP and the resultant extrapancreatic lesions appear to be lesions of IgG4-related systemic disease (IgG4-related sclerosing disease). | |