| Theme | GIST : Current Progress on Diagnosis and Treatment | |
|---|---|---|
| Title | New Treatment Strategy for Metastatic Gastrointestinal Stromal Tumors (GISTs) | |
| Publish Date | 2010/06 | |
| Author | Tatsuo Kanda | Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences |
| Author | Kaoru Sakamoto | Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences |
| Author | Atsushi Matsuki | Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences |
| Author | Kazuhito Yajima | Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences |
| Author | Shin-ichi Kosugi | Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences |
| Author | Katsuyoshi Hatakeyama | Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences |
| [ Summary ] | The clinical importance of a multimodal approach has increased for the treatment of metastatic gastrointestinal stromal tumors (GISTs). Surgery plays a significant role in GIST multimodality treatment. In Japan, surgical resection of hepatic metastasis from GIST is accepted as an optional treatment for selected patients with long recurrence-free intervals. Surgical resection of resistant tumors is occasionally selected in patients with limited progression of metastatic GISTs. The prognoses for GIST patients who underwent resection of responding and remaining tumors was good, suggesting great promise for multimodality treatment comprised of imatinib and surgery for metastatic GISTs. However, evidence levels for these surgical treatments are quite low. We should make an all-out effort to accumulate high-quality data in order to clarify the clinical significance of surgery in multimodal treatment of metastatic GISTs. | |