| Theme | Algorithm for Diagnosis and Treatment of Liver Cancer | |
|---|---|---|
| Title | Liver Resection for Hepatocellular Carcinoma | |
| Publish Date | 2010/04 | |
| Author | Hisashi Nakayama | Department of Digestive Surgery, Nihon University School of Medicine |
| Author | Tadatoshi Takayama | Department of Digestive Surgery, Nihon University School of Medicine |
| [ Summary ] | The safety of liver resection for hepatocellular carcinoma (HCC) has improved and it is reported that the mortality rate is now 0.7％. HCC has a high propensity to invade the portal vein. Vascular invasion and intrahepatic metastasis are among the risk factors that most strongly influence postoperative prognoses. Anatomical resection is theoretically effective for eradication of intrahepatic metastases of HCC. On the other hand, wide liver resection may lead to serious hepatic failure. Therefore, indication for liver resection are based on the relationship between liver function, hepatic functional reserves and profiles of HCC. In patients with the severity of the liver damage categorized as class A or B and if there are from one to three tumors, liver resection is recommended by the Japanese clinical practical guidelines for HCC. At this time, a randomization controlled trial evaluating the significance of anatomical resection is being conducted. | |