| Theme | Precancerous Conditions and Cancer High-risk Lesions in the Esophagus and the Stomach | |
|---|---|---|
| Title | Epstein-Barr Virus Infection and Gastric Cancer | |
| Publish Date | 2010/03 | |
| Author | Jun Nishikawa | Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine |
| Author | Mari Saito | Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine |
| Author | Toshiyuki Okada | Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine |
| Author | Yuki Fukagawa | Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine |
| Author | Shu Kiyotoki | Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine |
| Author | Kouichi Hamabe | Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine |
| Author | Takeshi Okamoto | Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine |
| Author | Yutaka Suehiro | Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine |
| Author | Yuji Hinoda | Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine |
| Author | Isao Sakaida | Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine |
| [ Summary ] | The Epstein-Barr virus(EBV) is detected in about 10% of gastric carcinoma cases throughout the world. In EBV-associated gastric carcinomas, all tumor cells harbor the clonal EBV genome. It is considered that EBV plays an important role in the development of EBV-associated gastric carcinomas. Most EBV-associated gastric carcinomas exhibit lymphocyte infiltration rich histology, which may indicate a relatively favorable prognosis in EBV-positive cases. The role of EBV in gastric epithelial oncogenesis is now being elucidated. Up-regulation of IGF1 (insulin-like growth factor 1) and DNA methylation of tumor suppressor genes may also be involved. | |