| Theme | Precancerous Conditions and Cancer High-risk Lesions in the Esophagus and the Stomach | |
|---|---|---|
| Title | Differential Diagnosis of Iodine -- unstained Areas | |
| Publish Date | 2010/03 | |
| Author | Toshiro Iizuka | Department of Gastroenterology, Toranomon Hospital |
| Author | Daisuke Kikuchi | Department of Gastroenterology, Toranomon Hospital |
| Author | Shu Hoteya | Department of Gastroenterology, Toranomon Hospital |
| Author | Naohisa Yahagi | Department of Gastroenterology, Toranomon Hospital |
| [ Summary ] | During endoscopic examination with iodine staining, various degrees of iodine-unstained areas were often found. Histologically, those areas are diagnosed as regions of inflammation, low grade intraepithelial neoplasia, high grade intraepithelial neoplasia (HGIN) or invasive cancer. Clinically, it is required that we distinguish various types of inflammatory lesions such as reflux esophagitis, non reflux esophagitis or radiation induced esophagitis from HGIN in terms of endoscopic features for iodine-unstained areas. For differential diagnosis, pink colored areas are one useful indicator. The sensitivity of this technique was 91.9%, and the specificity was 94%. The size, shape, and the demarcation of the iodine-unstained areas are also important. All these factors should be taken into consideration when target lesions are biopsied. | |