| Theme | Cutting Edge : Pathogenesis and Treatment of Hepatitis B | |
|---|---|---|
| Title | Natural Course of HBV Carriers | |
| Publish Date | 2009/06 | |
| Author | Hiroshi Yatsuhashi | Clinical Research Center, NHO Nagasaki Medical Center |
| Author | Sinya Nagaoka | Clinical Research Center, NHO Nagasaki Medical Center |
| Author | Naruhiro Hai | Clinical Research Center, NHO Nagasaki Medical Center |
| Author | Seigo Abiru | Clinical Research Center, NHO Nagasaki Medical Center |
| [ Summary ] | The natural course of HBV carriers was divided into five phases. 1) immune tolerance phase, 2) immune clearance phase (HBeAg+ chronic hepatitis B), 3) low replicative phase (inactive carrier state phase), 4) reactivation phase (HBeAg− chronic hepatitis B), and 5) recovery phase. Recently, high levels of serum HBV-DNA have come to be regarded as one high risk factor in the development of hepatocellular carcinoma related to persistent HBV infections. | |