| Theme | Intestinal Mucosal Damage Induced by Drugs | |
|---|---|---|
| Title | Diagnosis of Small Bowel Injuries Induced by NSAID | |
| Publish Date | 2009/12 | |
| Author | Satoshi Sugimori | Department of Gastroenterology, Osaka City University Graduate School of Medicine |
| Author | Toshio Watanabe | Department of Gastroenterology, Osaka City University Graduate School of Medicine |
| Author | Hirotoshi Okazaki | Department of Gastroenterology, Osaka City University Graduate School of Medicine |
| Author | Kazunari Tominaga | Department of Gastroenterology, Osaka City University Graduate School of Medicine |
| Author | Yasuhiro Fujiwara | Department of Gastroenterology, Osaka City University Graduate School of Medicine |
| Author | Tetsuo Arakawa | Department of Gastroenterology, Osaka City University Graduate School of Medicine |
| [ Summary ] | Recent advances in diagnostic methods, including capsule endoscopy and double-balloon endoscopy, have enabled us to examine the entire small bowel. We now recognize that NSAIDs often cause small bowel injury. NSAID-induced small bowel injury can be diagnosed based on age, clinical course, history of drug use, bacterial culture of fecal and biopsy samples, endoscopic findings, and histology as well as definite history of NSAID use. NSAIDs can injure both the jejunum and the ileum, which is important for differential diagnosis of other intestinal diseases such as Crohnʼs disease and chronic nonspecific multiple ulcers of the small intestine, because these intestinal diseases predominantly occur in the ileum. Circular ulcers or erosions are characteristic of NSAIDinduced small bowel injuries. |
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