| Theme | Intestinal Mucosal Damage Induced by Drugs | |
|---|---|---|
| Title | Drug Induced Enteropathy | |
| Publish Date | 2009/12 | |
| Author | Shunji Fujimori | Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School |
| Author | Yoko Takahashi | Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School |
| Author | Tsuguhiko Seo | Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School |
| Author | Yukie Yamada | Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School |
| Author | Atsushi Tatsuguchi | Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School |
| Author | Choitsu Sakamoto | Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School |
| [ Summary ] | Capsule endoscopy and double balloon endoscopy, advanced modalities that now allow for full investigation of the entire small intestine, have revealed that NSAIDs can cause a variety of abnormalities in the small intestine；such as ulcerations, perforation, bleeding and diaphragm-like stricture. Capsule endoscopy studies have shown that as little as a two week administration of conventional NSAIDs induce small intestinal damage in up to 60％ of healthy volunteers. Moreover, enteric coated low-dose aspirin also induces small intestinal damage in up to 50％ of healthy volunteers. In relation to the prevention of NSAID-induced small intestinal injury, several studies have already shown that celecoxib, a selective COX-2 inhibitor, effectively reduces mucosal breaks induced by 2 week treatment with NSAIDs. Recently, in Japan, misoprostol and rebamipide have been investigated for the prevention of NSAID-induced small intestinal injury. Confirmation of conditions with capsule endoscopy along with administration of misoprostol and rebamipide may prevent NSAID-induced macroscopic damage throughout the small intestine. | |