| Theme | Intestinal Mucosal Damage Induced by Drugs | |
|---|---|---|
| Title | Molecular Mechanisms of Intestinal Mucosal Damage Induced by NSAIDs | |
| Publish Date | 2009/12 | |
| Author | Kazuhiko Uchiyama | Molecular Gastroenterology and Hepatology, Kyoto Prefectual University of Medicine |
| Author | Yuji Naito | Molecular Gastroenterology and Hepatology, Kyoto Prefectual University of Medicine |
| Author | Toshikazu Yoshikawa | Molecular Gastroenterology and Hepatology, Kyoto Prefectual University of Medicine |
| [ Summary ] | At this time it is clear what the molecular mechanisms controlling intestinal mucosal damage induced by NSAIDs are. The mechanisms related to NSAID induced intestinal mucosal damage have focused on various factors including inflammation, apoptosis, oxidative stress, and nitric oxide. Experimental data, including ours, have shown that NSAIDs activate neutrophils and induce neutrophil infiltration into the intestinal mucosa, as well as induce TNF-alpha expression. This means that NSAIDs induce intestinal mucosal inflammation. NSAIDs also induce apoptosis of intestinal epithelial cells and increase oxidative stress inside epithelial cells. These findings have been illustrated in both vivo and in vitro experiments. Recently nitric oxide from inducible NOS has been reported to have an important role in NSAID induced intestinal mucosal damage. Since NSAID induced intestinal mucosal damage causes severe clinical problems, elucidation of molecular mechanism related to mucosal damage from NSAIDs is vital. | |