| [ Summary ] |
Familial hyperplastic polyposis (FHPP) is a rare disease which has been reported in only 7 families, with a total of 20 patients. The clinico-pathological characteristics of FHPP were as follows ; patient ages at diagnosis of FHPP, 22 - 77 (mean 57.1 years old), male / female ratio, 11 / 9 and colorectal lesions consisting of multiple hyperplastic polyps, some of which exceeded 10 mm in diameter, serrated adenomas, and tradifional adenomas. Seven (35 %) were affected by colonic carcinomas. The responsible gene for FHPP was not found. However, dominant or recessive inheritance patterns for FHPP were reported. Precise diagnosis of FHPP, including differential diagnosis from other familial digestive neoplastic diseases, is important. After a diagnosis of FHPP, surveillance for colorectal cancer and screening of diseases in all patient family members is necessary. |