| Theme | Recent Topics of Hereditary Colorectal Disease | |
|---|---|---|
| Title | Diagnosis and Management of Gastrointestinal Familial Adenomatous Polyposis Involvement | |
| Publish Date | 2008/08 | |
| Author | Kazuoki Hizawa | Department of Gastroenterology, Kyushu Central Hospital |
| Author | Ritsuko Fujisawa | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author | Takayuki Matsumoto | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author | Mitsuo Iida | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| [ Summary ] | Familial adenomatous polyposis (FAP) is a hereditary disease, frequently developing into colorectal cancer. Individual quality of life and potential risk of colorectal cancer affected by gene mutation should be considered in determination of prophylactic surgery. Sulindac induces regression of small colorectal adenomas, but seemingly has no preventive effect on colorectal cancer. FAP is related to various extracolonic conditions, including gastric fundic gland polyps (51 %), gastric adenomas (35 %), nonampullary duodenal adenomas (88 %), and ampullary adenomas (59 %). The incidence of upper gastrointestinal cancer is low, and periodic gastroduodenoscopies for cancer screening are recommended. | |