| Theme | Role of Endoscopy in the Diagnosis and Treatments of Pancreatic Diseases | |
|---|---|---|
| Title | Combined Treatment with Immunotherapy and Chemotherapy Using EUS Guided Injections for Inoperable Locally Advanced Pancreatic Cancer | |
| Publish Date | 2008/07 | |
| Author | Yoshiki Hirooka | Department of Endoscopy, Nagoya University Hospital |
| Author | Akihiro Itoh | Department of Gastroenterology, Nagoya University Graduate School of Medicine |
| Author | Hiroki Kawashima | Department of Gastroenterology, Nagoya University Graduate School of Medicine |
| Author | Koji Nonogaki | Department of Gastroenterology, Nagoya University Graduate School of Medicine |
| Author | Hidemi Goto | Department of Endoscopy, Nagoya University Hospital / Department of Gastroenterology, Nagoya University Graduate School of Medicine |
| Author | Kazuo Hara | Department of Gastroenterology, Aichi Cancer Center |
| [ Summary ] | Dendritic cell (DC) therapy frequently induces a measurable immune response. However, clinical responses are seen in a minority of patients, presumably due to insufficient expansion of antigen-specific CTLs, which are capable of eradicating tumour cells. The purpose of this trial was to increase the therapeutic efficacy of DC-based vaccinations. We undertook the first clinical trial involving a combination therapy employing gemcitabine (GEM) along with immunotherapy for patients with inoperable locally advanced pancreatic cancer. | |