| [ Summary ] |
The liver is the central organ responsible for metabolism of nutrients such as carbohydrates, fats, proteins, amino acids, and metabolic energy. Therefore, protein energy malnutrition (PEM) is easily induced in liver cirrhosis, causing ascites, edema, hepatic encephalopathy, and consequently worsening prognoses and QOL. Recently, it has become clear that administration of branched-chain amino acids (BCAA) is effective for treatment of liver cirrhosis. Resolution of hepatic encephalopathy through ammonia degradation, as well as improved protein synthesis are seen as key mechanisms. In addition, in recent years intervention with BCAA to prevent liver cancer has been proposed. |