| Theme | Present Status of Chemoprevention for Tumors Derived from Digestive Diseases | |
|---|---|---|
| Title | Cancer Chemoprevention-Radical Perspective | |
| Publish Date | 2008/11 | |
| Author | Satoshi Kokura | Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science |
| Author | Toshikazu Yoshikawa | Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science |
| [ Summary ] | It is believed that oxidative stress or free radical reactions are carcinogenis agents. Therefore, antioxidants have long been thought to be chemopreventative agents for cancer treatment. Epidemiologic studies, have suggested that high intake of fruit and vegetables which are rich in antioxidants has cancer chemopreventative effects. However, there are few reports which confirm the cancer chemoprevention effects of antioxidants in human clinical trials. Recently, it has been reported that some antioxidant materials have shown prooxidative effects. In this report, we provide an outline concerning the cancer chemopreventative properties of antioxidant materials. |
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