| Theme | Present Status of Chemoprevention for Tumors Derived from Digestive Diseases | |
|---|---|---|
| Title | Chemoprevention and Glutathione S-transferase-pi | |
| Publish Date | 2008/11 | |
| Author | Tetsuji Takayama | Department of Gastroenterology and Oncology, Institutes of Health Biosciences, the University of Tokushima Graduate School |
| Author | Naoki Muguruma | Department of Gastroenterology and Oncology, Institutes of Health Biosciences, the University of Tokushima Graduate School |
| Author | Toshiya Okahisa | Department of Gastroenterology and Oncology, Institutes of Health Biosciences, the University of Tokushima Graduate School |
| Author | Seisuke Okamura | Department of Gastroenterology and Oncology, Institutes of Health Biosciences, the University of Tokushima Graduate School |
| Author | Yoshiro Niitsu | 4th Department of Internal Medicine. Sapporo Medical University School of Medicine |
| [ Summary ] | Glutathione S-transferase-pi is a multifunctional protein whose various functions include the formation of glutathione conjugates, the binding of anticancer drugs, and the reduction of lipid peroxides. GST-pi is overexpressed in gastrointestinal cancers such as colonic cancer, pancreatic cancer, gall bladder cancer, etc. It is also expressed in precancerous lesions, including colonic adenoma and aberrant crypt foci (ACF), a precursor lesion of colonic adenoma and subsequent cancer. It is suggested that GST-pi promotes cell growth and inhibits apoptosis. Since the expression of GST-pi is very limited in normal tissue, except in the placenta, it appears to be a promising target for chemoprevention. In fact, a GST-pi inhibitor inhibited the formation of ACF and cancer in animal models of colon chemical carcinogenesis. | |