| Theme | Present Status of Chemoprevention for Tumors Derived from Digestive Diseases | |
|---|---|---|
| Title | Gastric Cancer Chemoprevention Employing Helicobacter pylori Eradication | |
| Publish Date | 2008/11 | |
| Author | Mototsugu Kato | Division of Endoscopy, Hokkaido University Hospital |
| Author | Shouko Ono | Division of Endoscopy, Hokkaido University Hospital |
| Author | Rumiko Asaka | Department of Gastroenterology, Hokkaido University Graduate School of Medicine |
| Author | Keiko Yamamoto | Department of Gastroenterology, Hokkaido University Graduate School of Medicine |
| Author | Urara Nishida | Department of Gastroenterology, Hokkaido University Graduate School of Medicine |
| Author | Aki Imai | Department of Gastroenterology, Hokkaido University Graduate School of Medicine |
| Author | Hiroaki Makiyama | Department of Gastroenterology, Hokkaido University Graduate School of Medicine |
| Author | Takeshi Yoshida | Department of Gastroenterology, Hokkaido University Graduate School of Medicine |
| Author | Yuichi Shimizu | Department of Gastroenterology, Hokkaido University Graduate School of Medicine |
| Author | Masahiro Asaka | Department of Gastroenterology, Hokkaido University Graduate School of Medicine |
| Author | Manabu Nakagawa | Nakagawa Ichouka |
| Author | Souichi Nakagawa | Nakagawa Ichouka |
| [ Summary ] | Helicobacter pylori (H. pylori) plays an important role in gastric carcinogenesis, because the vast majority of gastric cancers, including the intestinal type and the diffuse type, develop from background of H. pylori infection of the gastric mucosa. The relationship between H. pylori infection and the development of gastric cancer was proven through epidemiological, animal experimental, and clinical studies. Therefore, eradication of H. pylori has the potential to reduce the incidence of gastric cancer. In experimental studies using Mongolian Gerbils, the effect of H. pylori eradication was proven for prophylaxis of gastric cancers. Non-randomized trials in Japan have confirmed that eradicating H. pylori is effective in suppressing the incidence of gastric cancer. However, a large-scale randomized placebo controlled interventional study in China revealed in significant results concerning the prophylactic effects of H. pylori eradication. On the other hand, a multi-center randomized study in Japan indicated that H. pylori eradication significantly suppress the development of secondary early gastric cancer after endoscopic treatment for primary early gastric cancer. To reduce the mortality rates for gastric cancer in Japan, we must establish public a system, through which the prevention of gastric cancer by H. pylori eradication may be achieved. | |