| Theme | Pit Pattern Classification in colorectal Lesion | |
|---|---|---|
| Title | Morphogenesis of Colorectal Neoplasms in Relation to Isolated Crypts | |
| Publish Date | 2008/10 | |
| Author | Satoru Tamura | Division of Gastroenterology, Tamura Clinic |
| Author | Yasuo Furuya | Division of Surgery, Atago Hospital |
| [ Summary ] | The goal of this study was to clarify morphogenetic development from the viewpoint of isolated crypts and pit patterns in colorectal neoplasms. The HCI-digestion method was used for crypt isolation. In colorectal tumors with type IIIL pit pattern, isolated crypts from protruded type tumors displayed greater roughness with budding on their surface structures. Non-granular type laterally spreading tumors (LST-NG) with type IIIL pit pattern, and isolated crypts displayed frontal formation, that is, the surface area was tumorous but the bottom was non-tumorous. The crypt orifice revealed type IIIs pit pattern, revealing crypts both with and without fission from the bottom. Colorectal neoplasms with depressions enlarge by the process of crypt bifurcation, in which a single crypt divides into two crypts. These results indicate that colorectal neoplasms with depressions enlarge through the process of "crypt fission" in which a single crypt divides into two crypts, LST-NG type neoplasms enlarge through the process of "top-down morphogenesis", and neoplasms with protrusion enlarge through the process of "budding". |
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