| Theme | Digestive Diseases Related to Bacteria -- To Understand Etiology and Control of Clinicopathological Conditions | |
|---|---|---|
| Title | Correlations between Alcoholic Steatohepatitis, Nonalcoholic Steatohepatitis and Intestinal Bacteria | |
| Publish Date | 2007/08 | |
| Author | Toshifumi Ohkusa | Department of Gastroenterology, Juntendo University School of Medicine |
| Author | Nobuhiro Sato | Osaka Police Hospital |
| [ Summary ] | It is hypothesized that is relation to alcoholic steatohepatitis, ethanol consumption increase the permeability of the small intestine and endotoxins are produced which incite necroinflammatory changes in connection steatohepatitis and hepatic fibrosis. Endotoxins are potent inducers of proinflammatory and cytotoxic cytokines, such as tumor necrosis factorα (TNF-α) from activated macrophages, including Kupffer cells. It is known that severe steatohepatitis occurres after jejunoileal bypass surgery for obesity and resection of the redundant intestinal loop with its bacterial flora, or treatment with antibiotics for small intestinal bacterial overgrowth (SIBO) improves nonalcoholic steatohepatitis (NASH) in rat models of jejunoileal-bypass liver disease. It has been reported that patients with NASH have a higher prevalence of SIBO. These findings suggest that gut derived bacterial endotoxins could be involved in triggering liver injury in conjunction with NASH. Recently, intestinal bacteria have been studied with new molecular, biological techniques instead of the culture method. Therefore, it is proposed that causal bacteria in portal NASH blood should be searched for. Causal bacteria derived endotoxins, related to NASH, have been detected. Eradication therapy for the bacteria may bring improvements in NASH. |
|