| Theme | Digestive Diseases Related to Bacteria -- To Understand Etiology and Control of Clinicopathological Conditions | |
|---|---|---|
| Title | Infectious Diseases in Oral Cavity | |
| Publish Date | 2007/08 | |
| Author | Masatake Asano | Department of Pathology, Nihon University School of Dentistry |
| Author | Itaru Moro | Advanced Research Institute for the Sciences and Humanities, Graduate School of Nihon University |
| [ Summary ] | Over 500 bacterial species live in the oral cavity. Dental caries and periodontal diseases are two major infectious diseases of the oral cavity. The oral flora play important roles in the incidence of these diseases. Periodontal diseases are classified into two types, periapical and marginal periodontitis. Dental plaques are complex microbial communities and are of considerable clinical importance as primary etiologic agents in the development of marginal periodontitis. The surface of the oral mucosa is covered with squamous epithelial cells and many types of mucosal diseases can be found in this area. Recurrent aphthous stomatitis (RAS) is characterized by multiple recurrent small, round ulcers with circumscribed margins, erythematous haloes, and yellow or gray floors.Behçet's disease (BD) is a multi-system disorder with clinical features similar to RAS. Although the etiology of these diseases is not entirely clear, the contribution of heat shock protein (HSP)-derived antigens to the development of these diseases has been reported recently. In this review, an attempt was made introduce the features of marginal periodontitis, RAS and BD. The importance of bacterial components in the pathogenesis of these diseases is discussed. |
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