| Theme | NASH : An Update | |
|---|---|---|
| Title | NASH, Oxidative Stress and Hepatic Fibrosis | |
| Publish Date | 2007/10 | |
| Author | Hideki Fujii | Department of Hepatology, Graduate School of Medicine, Osaka City University |
| Author | Kohji Otogawa | Department of Hepatology, Graduate School of Medicine, Osaka City University |
| Author | Norifumi Kawada | Department of Hepatology, Graduate School of Medicine, Osaka City University |
| [ Summary ] | Oxidative stress plays an important role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Production of reactive oxygen species (ROS), is closely related to the excessive inflow of diet-derived fatty acids to the liver, in combination with multiple cytokine generation due to NF-κB activation, which induce hepatocyte death and local inflammation. On the other hand, ROS are known to directly activate hepatic stellate cells, principle collagen producing cells in the liver, leading to the initiation of fibrotic responses. Thus, oxidative stress is considered to play significant roles in the development of fibrosis in NASH. | |