| Theme | NASH : An Update | |
|---|---|---|
| Title | NASH and Oxidative Stress | |
| Publish Date | 2007/10 | |
| Author | Hirofumi Uto | Department of Digestive and Life-style related Disease, Kagoshima University Graduate School of Medical and Dental Sciences |
| Author | Makoto Oketani | Department of Digestive and Life-style related Disease, Kagoshima University Graduate School of Medical and Dental Sciences |
| Author | Akio Ido | Department of Digestive and Life-style related Disease, Kagoshima University Graduate School of Medical and Dental Sciences / Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital |
| Author | Hirohito Tsubouchi | Department of Digestive and Life-style related Disease, Kagoshima University Graduate School of Medical and Dental Sciences / Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital |
| [ Summary ] | Oxidative stress, which plays an important role in the pathogenesis of nonalcoholic steatohepatitis (NASH), is characterized by an excess level of reactive oxygen species (ROS), and is associated with hepatocyte injury, hepatic fibrosis, and hepatocarcinogenesis. The levels of oxidative stress markers in cases of NASH or nonalcoholic fatty liver disease (NAFLD) are higher than in simple steatosis or healthy control subjects, respectively. These observations indicate that suppression of oxidative stress is a promising potential treatment for NAFLD and NASH. | |