| Theme | Guidebook of Pathology for Gastroenterologists and Hepatologists ; Including Special Stains and Immunohistochemistry | |
|---|---|---|
| Title | Common Invasive Ductal Carcinoma, Invasive Carcinoma Derived from IPMNs and Mucinous Cystic Neoplasms of the Pancreas | |
| Publish Date | 2007/09 | |
| Author | Akio Yanagisawa | Department of Pathology, Kyoto Prefectural University of Medicine |
| Author | Satoru Yasukawa | Department of Pathology, Kyoto Prefectural University of Medicine |
| [ Summary ] | The existence of 2 pathways for the development of invasive ductal adenocarcinoma of the pancreas has been elucidated : (1) the adenoma-carcinoma sequence in which tumors progress via intraductal papillary-mucinous neoplasms (ie, Invasive carcinoma derived from IPMNs : Inv-IPMNs) ; and (2) the denovo pathway in which tumors do not progress via adenoma (ie, common invasive ductal carcinoma : Inv-DC). Age, gender, and tumor location are similar among Inv-IPMNs and Inv-DC. As for the histological type of the invasive component, the frequency of mucinous adenocarcinoma in the Inv-IPMNs is higher than in Inv-DC. The rate of lymph node metastasis in Inv-DC is higher than in Inv-IPMNs. Massive mucin production and common histological characteristic forming papillary projections are similar in mucinous cystic neoplasms (MCNs) and IPMNs. However, they are many differences. The predominant differentiating features are evident in terms of age and sex distribution, intrapancreatic localization, size, presence of capsules, mode of compartmentalization, communication with the main pancreatic duct and ovarian-type stroma. |
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