| Theme | Guidebook of Pathology for Gastroenterologists and Hepatologists ; Including Special Stains and Immunohistochemistry | |
|---|---|---|
| Title | Pathological Diagnosis of Early Colorectal Cancer ; Biological Behavior in Association with Grades of Atypia, Mucin Phenotypes and Growth Patterns, and Significance of Serrated Lesions | |
| Publish Date | 2007/09 | |
| Author | Takashi Yao | Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University |
| Author | Yutaka Koga | Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University |
| Author | Masaki Gushima | Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University |
| Author | Masazumi Tsuneyoshi | Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University |
| [ Summary ] | This is an outline concerning significant factors related to biological behavior such as cytologic atypia, phenotypic expression and colorectal carcinoma growth patterns as well as the significance of serrated lesions. In regard to cytologic atypia, adenocarcinoma with high grade atypia tends to be more aggressive than that with low grade atypia. In phenotypic expression, CD 10 positive adenocarcinoma tends to be more aggressive, with high incidences of venous invasion and liver metastasis than other types. Concerning growth patterns, non-polypoid growth tends to be more aggressive than that with polypoid growth. In relation to serrated lesions, the concept of sessile serrated polyps has recently been proposed. This has drawn attention to these early lesions as new carcinogenetic pathways. However, the significance of these lesions remains to be proven. |
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