| Theme | Guidebook of Pathology for Gastroenterologists and Hepatologists ; Including Special Stains and Immunohistochemistry | |
|---|---|---|
| Title | Pathological Diagnosis of Early Colorectal Cancer : Histological Type of Epithelial Lesion in Colorectal Mucosa, Degree of Invasion for Carcinoma Invade into Submucosal Layer and Prognostic Factors | |
| Publish Date | 2007/09 | |
| Author | Shigeharu Hamatani | Department of Pathology, Showa University Northern Yokohama Hospital |
| Author | Tomokazu Hisayuki | First Department of Pathology, Showa University |
| Author | Akira Shiokawa | Department of Pathology, Showa University Northern Yokohama Hospital |
| Author | Nobunao Ikehara | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author | Hiroshi Kashida | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author | Shin-ei Kudo | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| [ Summary ] | Epithelial lesions in the colorectal mucosa form a proliferation zone with various patterns based on differences in character. Ki-67 immunostain is used for identification of proliferation zones. When judging the degree of carcinomial invasion into the submucosal layer (Ca SM), desmin immunostain is utilized. The muscularis mucosae (MM) run becomes ambiguous with the invasion of cancer. A virtual run of MM can be assumed if remnants of smooth muscle bundles are detected with desmin immunostain. Vessel invasion and sprouting are prognostic factors for colorectal Ca SM. Histochemical staining for elastic fibers and endothelial markers (CD 34, CD 31, D 2-40) with immunostaining enable more objective judgments concerning vessel invasion. Isolated cancer cells or small numbers of these cells in the invasive front are termed “sprouting”, and are related to lymph vessel invasion or lymph node metastasis. | |