| Theme | Guidebook of Pathology for Gastroenterologists and Hepatologists ; Including Special Stains and Immunohistochemistry | |
|---|---|---|
| Title | Pathological Diagnosis of Liver Tumors | |
| Publish Date | 2007/09 | |
| Author | Rie Irie | Division of Diagnostic Pathology, Keio University School of Medicine |
| Author | Yohei Masugi | Department of Pathology, Keio University School of Medicine |
| Author | Kathryn Effendi | Department of Pathology, Keio University School of Medicine |
| Author | Michiie Sakamoto | Department of Pathology, Keio University School of Medicine |
| [ Summary ] | Liver tumors are divided into two main categories, epithelial tumors and non-epithelial tumors. Epithelial tumors include hepatocellular, cholangiocellular, combined, and metastatic tumors. AFP and hepatocyte antigens are immunohistochemical markers used for hepatocellular tumors, and CA 19-9, cytokeratin 7 and 19 are used for cholangiocellular tumors. Cytokeratin 7 and 20 are useful markers to make differential diagnoses between cholangiocellular carcinoma and metastatic colon cancers. Angiomyolipoma and epithelioid hemangioendothelioma are non-epithelial liver tumors, which resemble epithelial tumors and are sometimes difficult to diagnoses. HMB-45 and SMA antigens are immunohistochemical markers used for angiomyolipoma and endothelial markers are used for epithelioid hemangioendothelioma diagnosis. It is important to consider these tumors when diagnosing liver tumors. | |