| Theme | Candidate Causes of H. pylori-Negative Gastric Cancer | |
|---|---|---|
| Title | Projection of Gastric Cancer Incidence in H. pylori Negative Era ; Assessment of Combining H. pylori Antibodies and Serum Pepsinogen Status | |
| Publish Date | 2006/07 | |
| Author | Hirotsugu Watabe | Department of Gastroenterology, University of Tokyo |
| Author | Yutaka Yamaji | Department of Gastroenterology, University of Tokyo |
| Author | Toru Mitsushima | Kameda General Hospital |
| Author | Masao Omata | Department of Gastroenterology, University of Tokyo |
| [ Summary ] | Helicobacter pylori (Hp) infection rates have been declining over the past 2 - 3 decades. We analyzed cohort studies on 6,983 subjects annually followed up on to assess possible changes in gastric cancer incidence in the future. We classified the cohort studies into 4 groups : according to Helicobacter pylori antibodies (HpAb) and pepsinogen status (PG) ; group A (HpAb− and PG−), group B (HpAb+ and PG−), group C (HpAb+ and PG+), and group D (HpAb− and PG+). During the follow up (4.7 years), 43 gastric cancers developed. The annual incidence of gastric cancer was 0.04 %, 0.06 %, 0.13 % and 0.60 % in groups A, B, C, and D, respectively. We established a super high risk group, males over 60 years in group D. They had the annual incidence of 1.8 %. Group A was assumed to have no Hp infection, whereas groups B, C, and D were infected with Hp. A decrease in Hp infection leads to an increase in the proportion in group A. Finally, it was projected that gastric cancer incidence will decline in the future. |
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