| Theme | Candidate Causes of H. pylori-Negative Gastric Cancer | |
|---|---|---|
| Title | Remnant Gastritis and Gastric Carcinoma | |
| Publish Date | 2006/07 | |
| Author | Masahiro Ochiai | Department of Surgery, Fujita Health University School of Medicine |
| Author | Yoichi Sakurai | Department of Surgery, Fujita Health University School of Medicine |
| Author | Ichiro Uyama | Department of Surgery, Fujita Health University School of Medicine |
| Author | Yosiyuki Komori | Department of Surgery, Fujita Health University School of Medicine |
| Author | Yasuko Nakamura | Department of Surgery, Fujita Health University School of Medicine |
| Author | Mitsutaka Shoji | Department of Surgery, Fujita Health University School of Medicine |
| [ Summary ] | The mucosa of the post-gastrectomized remnant stomach has a high potential for developing stump carcinoma. The main reason for the high risk is considered to be gastritis caused by duodenal juice reflux into the stomach. Another cause of the risk is considered to be H. pylori infection. However, there is still controversy as to whether the incidence of infection in the remnant stomach is high or low. The carcinogenic potential of reflux gastritis has been proven by many animal based experiments in the past, as well as many clinical experiences. We found accelerated proliferating activities and p 53 gene aberrations in the mucosal cells of gastritis cystica polyposa, which is a specific type of chronic reflux gastritis. | |