| [ Summary ] |
A Mendelian model, with associated environmental factors, corresponds with familial occurrence of gastric cancer in Japan. Associated studies, stratified with matched confounding studies are necessary to identify the responsible genetic polymorphism of gastric cancer, including P 450, detoxifying genes, and repair genes. Typical hereditary diffuse gastric cancer (HDGC) is unknown in Japan. Most anecdotal pedigrees are a waiting further genetic investigation. Genome wide microarray analysis would allow us to identify quantitative risk factors for gastric cancer and eventually identify other, causal factors for familial gastric cancer. |