| Theme | Current Status of Magnifying Endoscopy | |
|---|---|---|
| Title | Diagnosis of Esophageal Squamous Cell Carcinoma | |
| Publish Date | 2006/04 | |
| Author | Youichi Kumagai | Department of Surgery, Ohta Nishinouchi Hospital |
| Author | Shigeru Yamazaki | Department of Surgery, Ohta Nishinouchi Hospital |
| Author | Michio Iida | Department of Surgery, Ohta Nishinouchi Hospital |
| [ Summary ] | Early detection of superficial esophageal cancer is indispensable in order to promote improvements in QOL for patients. This article comments on findings which led to early diagnosis of esophageal cancer with a Q240Z system having 100 power magnification, and an Endo-Cytoscopy System with 450 and 1125 power (Olympus). Observation with the Q240Z system observed the intra-papillary capillary loop (IPCL) of normal esophageal mucosa. IPCL presented abnormal findings of “dilation, weaving, changes of caliber and variety of shapes” in cancer. Vital staining is necessary with methylene blue in Endo-Cytoscopy Systems. By observing the normal esophageal mucosa with Endo-Cytoscopy Systems, using methylene blue staining, we were able to visualize those cells existent at the surface of the squamous epitherium. Those cells were arranged in a homogenous manner and the nucleus-cytoplasmic ratio was uniform and low. In the observation of the esophageal cancer, the density of cells increased greatly, compared to the normal squamous epithelium. Cell distribution was irregular with extreme heterogeneity of the cells with nuclei of different staining ratios, size and shape. The nucleus-cytoplasm ratio was very irregular. |
|