| Theme | Neuroendocrine Tumor of the Gastrointestinal Tract | |
|---|---|---|
| Title | Pathology, Diagnosis and Treatment on Colorectal Neuroendocrine Carcinoma | |
| Publish Date | 2006/09 | |
| Author | Noriko Kimura | Department of Pathology and Laboratory Medicine, Tohoku Rosai Hospital, Japan Labor and Welfare Organization |
| Author | Tatsuo Oriuchi | Department of Gastrointestinal Disease and lnternal Medicine, Tohoku Rosai Hospital, Japan Labor and Welfare Organization |
| Author | Hiroki Maekawa | Department of Gastrointestinal Disease and lnternal Medicine, Tohoku Rosai Hospital, Japan Labor and Welfare Organization |
| Author | Tetsuro Ogasawara | lnternal Medicine, Tohoku Rosai Hospital, Japan Labor and Welfare Organization |
| Author | Haruo Ohtani | Department of Pathology, National Hospital Organization, Mito Medical Center |
| [ Summary ] | Colorectal neuroendocrine carcinomas are classified into three subtypes: carcinoid (including atypical carcinoid), small cell carcinoma, and large cell neuroendocrine carcinoma(LCNEC) as counterparts to lung endocrine tumors. The majority of the tumors are carcinoid and the incidence of the other two types is quite low ; LCNEC has been previously reported only twenty cases to date. For pathologic diagnosis, it is necessary to confirm immunohistochemical reactivity to one of the following neuroendocrine markers : chromogranin A or B, synaptophysin, or neural cell adhesion molecule (NCAM), but not to neuron specific enolase (NSE). Colorectal neuroendocrine carcinomas express somatostatin receptors. A possible treatment for these tumors is a somatostatin analogue combined with some cytotoxic chemotherapy. | |