| Theme | The Latest Frontier of Endoscopy | |
|---|---|---|
| Title | Clinical Applications for Endoscopic Optical Coherence Tomography (EOCT) | |
| Publish Date | 2006/01 | |
| Author | Kenjiro Yasuda | Department of Gastroenterology, Kyoto Second Red Cross Hospital |
| Author | Masatoshi Miyata | Department of Gastroenterology, Kyoto Second Red Cross Hospital |
| Author | Moose Ueda | Department of Gastroenterology, Kyoto Second Red Cross Hospital |
| Author | Koji Uno | Department of Gastroenterology, Kyoto Second Red Cross Hospital |
| Author | Kiyohito Tanaka | Department of Gastroenterology, Kyoto Second Red Cross Hospital |
| Author | Eisai Cho | Department of Gastroenterology, Kyoto Second Red Cross Hospital |
| Author | Masatsugu Nakajima | Department of Gastroenterology, Kyoto Second Red Cross Hospital |
| Author | Yoshinobu Okabe | |
| [ Summary ] | Improved imaging diagnosis has been developed with technological advances. Optical coherence tomography (OCT) is a new technique for producing high resolution cross-sectional imagings approxinately 10 times greater than the 30 MHz ultrasound catheter probe by using broad-bandwidth illumination. In order to evaluate the diagnostic possibilities of OCT with endoscopy, GI tract and pancreato-biliary lesions were investigated. An OCT probe, 2.4 mm in diameter, with 2,000 mm of working length producing a 360 degree radial image, was used for this study by introducing the probe through the working channel of the endoscope. Scanning was conducted by having the probe contact the target wall and also with a non-contact method. The effective imaging range of EOCT was 1.0 to 1.5 mm. A normal esophageal wall can be demonstrated as a homogenous high reflective layer which corresponds to the mucosa, and the mucosal muscle, demonstrated as a low reflective layer. The cancerous region was observed as a thickening of the homogenous first layer. The gastric mucosa demonstrated a highly reflective layer with longitudinal glandular structures. The gastric submucosa was demonstrated as a low reflective layer. The cancerous region was observed as a lower reflective area. The normal bile duct wall was also demonstrated by intraductal OCT scanning. Penetration into the pancreatic parenchyma was less than that of bile duct wall. EOCT showed the microstructure of the GI tract mucosal layer, though penetration was limited. In addition analysis of OCT images is still problematic. | |