| Theme | GIST (gastrointestinal stromal tumor) | |
|---|---|---|
| Title | Prognostic Indicators for GIST | |
| Publish Date | 2005/08 | |
| Author | Takashi Tashiro | Clinical Laboratory Division, National Cancer Center Hospital |
| Author | Tadashi Hasegawa | Department of Clinical Pathology, Sapporo Medical University School of Medicine |
| [ Summary ] | We have reviewed in this article the clinicopathologic and immunohistochemical proliferating cell related parameters associated with the biological behavior of gastrointestinal stromal tumors (GIST). Both tumor size and mitotic index are important morphological factors for grading of GIST. Recently, an objective MIB-1 labeling index (LI) has been used for assessing the degree of malignancy in a variety of tumors, including GIST, with immunohistochemical staining with a monoclonal antibody MIB-1. This is used to counteract proliferating cell associated antigen Ki-67. It has been clarified that a risk classification based on a combination of tumor size and histologic grade assessed by either MIB-1 LI or tumor necrosis is of great advantage in predicting the prognosis of GIST. This prognostic classification, depending on reliable and reproducible MIB-1 LI for GIST, is highly recommended for grading, especially when examining small pre-operative, endoscopic biopsy specimens. | |